The back squat is a foundational strength-training exercise, well known for building powerful legs, increasing maximal strength, and supporting athletic performance. However, beyond these commonly discussed benefits, there are several less obvious — but scientifically significant — advantages that make the back squat one of the most valuable exercises you can perform.
This article examines five unusual benefits of back squats that are backed by peer-reviewed scientific research. Each section delves into the mechanisms behind the benefit, discusses relevant studies, and explains how to incorporate this knowledge into training for optimal results.
1. Enhanced Hormonal Response Beyond Testosterone
When people talk about squats and hormones, the focus is usually on testosterone. While this anabolic hormone is indeed stimulated by heavy squatting, the broader endocrine response is often overlooked.
Growth Hormone and IGF-1
Research shows that multi-joint exercises involving large muscle groups, like the back squat, stimulate substantial acute increases in growth hormone (GH) and insulin-like growth factor 1 (IGF-1) (Kraemer et al., 1990). These hormones are critical not only for muscle hypertrophy but also for tissue repair, bone growth, and metabolic health.

A study by Hansen et al. (2001) found that performing compound lifts before isolation exercises resulted in significantly higher systemic GH levels, which in turn enhanced protein synthesis for hours after training. This means that strategically placing squats early in a workout could amplify the anabolic effects on all subsequent exercises.
Cortisol Regulation
While cortisol is often seen as a “bad” stress hormone, it plays a crucial role in energy mobilization during training. Research by Smilios et al. (2003) indicates that trained individuals can experience a favorable cortisol-to-testosterone ratio from regular heavy squat training, which is associated with improved adaptation and recovery.
2. Improved Spinal Loading Tolerance and Bone Density
Squats are sometimes criticized for being “bad for your back,” yet under correct technique and progressive loading, they can make your spine more resilient.
Bone Mineral Density
Multiple studies confirm that mechanical loading from resistance training increases bone mineral density (BMD) (Kohrt et al., 2004). The axial load of a barbell back squat stimulates osteoblast activity in the vertebrae and hips, areas prone to osteoporosis in aging populations.

In a landmark trial by Guadalupe-Grau et al. (2009), participants who performed loaded squats twice weekly showed significant increases in lumbar spine and femoral neck BMD after just six months. This benefit extends beyond athletes to anyone seeking to improve long-term skeletal health.
Intervertebral Disc Health
Although high-impact activities can sometimes degrade spinal discs, controlled axial loading via squats has been shown to maintain disc hydration and resilience (Belavy et al., 2017). These adaptations may reduce the risk of degenerative disc disease over time, provided that proper technique and load management are observed.
3. Increased Rate of Force Development (RFD) for Non-Leg Activities
Most people associate squats with improving jump height or sprint speed. However, one lesser-known benefit is their transfer to upper-body explosive power.
Neuromuscular Adaptation
The central nervous system (CNS) plays a key role in explosive movement. Heavy squats train the CNS to recruit high-threshold motor units more efficiently, improving the rate of force development (RFD) even in non-leg-dominant activities (Cormie et al., 2011).
A study by Haff et al. (2005) demonstrated that athletes who incorporated heavy squats into their training improved their performance in upper-body power tests, such as medicine ball throws, due to systemic neural adaptations.
Cross-Transfer of Force Production
The phenomenon of “cross-education” suggests that training one area can improve performance in another through neural cross-talk (Carroll et al., 2006). In practical terms, squats help your brain and nervous system become better at producing force, benefiting movements like Olympic lifts, throwing sports, and even striking power in combat athletes.
4. Improved Mobility Through Eccentric Loading
Back squats, when performed through a full range of motion, offer a unique mobility advantage — especially in the hips, ankles, and thoracic spine.
Eccentric Strength and Flexibility
Eccentric loading (lowering the bar under control) induces structural and neurological adaptations in muscle-tendon units that increase flexibility without passive stretching (O’Sullivan et al., 2012). Squatting below parallel forces the hip adductors, glutes, and calves into deep joint angles under load, encouraging greater active range of motion.

A 2019 study by Kubo et al. found that subjects performing deep back squats improved passive and active ankle dorsiflexion significantly more than those performing only partial squats. This mobility benefit has direct implications for injury prevention and athletic performance.
Joint Health
Contrary to the belief that deep squats harm knees, Hartmann et al. (2013) demonstrated that full squats produce less shear stress on the knee joint compared to partial squats when adjusted for load. The controlled eccentric phase strengthens connective tissues, improving joint stability and resilience.
5. Enhanced Metabolic Efficiency and Glucose Regulation
One of the least discussed but highly impactful benefits of squats is their role in metabolic health, particularly in glucose regulation.
Muscle Mass and Glucose Uptake
Skeletal muscle is the largest site for glucose disposal in the body. Squat training increases lower-body muscle mass, enhancing the muscle’s capacity to uptake glucose via GLUT-4 transporters (Holten et al., 2004). This has been shown to improve insulin sensitivity, reducing the risk of type 2 diabetes.
Acute Metabolic Boost
A study by Borer et al. (2012) found that high-intensity resistance training, such as heavy squatting, increases post-exercise oxygen consumption (EPOC) and metabolic rate for up to 24 hours post-training. The high muscle recruitment and energy demand of squats mean they are particularly effective at improving metabolic flexibility — the body’s ability to switch between fuel sources efficiently.
Practical Application
To reap these unusual benefits, consider these guidelines:
- Train Heavy and Smart: Use compound loading in the 70–90% 1RM range for optimal hormonal and neural adaptations.
- Prioritize Technique: Correct form maximizes benefits and minimizes injury risk.
- Incorporate Full Range of Motion: Go deep for mobility and joint health benefits, provided flexibility and form are sufficient.
- Periodize Training: Alternate heavy, explosive, and volume-based squat sessions to target different adaptations.
- Pair with Complementary Exercises: Use squats as a foundation for both lower and upper-body strength improvements.
Bibliography
- Belavy, D. L., Quittner, M., Ridgers, N. D., Ling, Y., Connell, D., & Rantalainen, T. (2017). Running exercise strengthens the intervertebral disc. Scientific Reports, 7, 45975.
- Borer, K. T., Wuorinen, E., Chao, C., & Burant, C. (2012). Exercise energy expenditure is not consciously detected due to oro-sensory modulation of ghrelin and hunger during exercise. Appetite, 59(2), 598–605.
- Carroll, T. J., Herbert, R. D., Munn, J., Lee, M., & Gandevia, S. C. (2006). Contralateral effects of unilateral strength training: evidence and possible mechanisms. Journal of Applied Physiology, 101(5), 1514–1522.
- Cormie, P., McGuigan, M. R., & Newton, R. U. (2011). Developing maximal neuromuscular power. Sports Medicine, 41(1), 17–38.
- Guadalupe-Grau, A., Fuentes, T., Guerra, B., & Calbet, J. A. (2009). Exercise and bone mass in adults. Sports Medicine, 39(6), 439–468.
- Haff, G. G., Carlock, J. M., Hartman, M. J., Kilgore, J. L., Kawamori, N., Jackson, J. R., Morris, R. T., Sands, W. A., & Stone, M. H. (2005). Force–time curve characteristics of dynamic and isometric muscle actions of elite women Olympic weightlifters. Journal of Strength and Conditioning Research, 19(4), 741–748.
- Hansen, S., Kvorning, T., Kjaer, M., & Sjøgaard, G. (2001). The effect of short-term strength training on human skeletal muscle: the importance of physiologically elevated hormone levels. Scandinavian Journal of Medicine & Science in Sports, 11(6), 347–354.
- Hartmann, H., Wirth, K., Klusemann, M., Dalic, J., Matuschek, C., & Schmidtbleicher, D. (2013). Influence of squatting depth on jumping performance. Journal of Strength and Conditioning Research, 27(12), 3416–3422.
- Holten, M. K., Zacho, M., Gaster, M., Juel, C., Wojtaszewski, J. F., & Dela, F. (2004). Strength training increases insulin-mediated glucose uptake, GLUT4 content, and insulin signaling in skeletal muscle in patients with type 2 diabetes. Diabetes, 53(2), 294–305.
- Kohrt, W. M., Bloomfield, S. A., Little, K. D., Nelson, M. E., & Yingling, V. R. (2004). Physical activity and bone health. Medicine & Science in Sports & Exercise, 36(11), 1985–1996.
- Kraemer, W. J., Marchitelli, L., Gordon, S. E., Harman, E., Dziados, J. E., Mello, R., Frykman, P., McCurry, D., & Fleck, S. J. (1990). Hormonal and growth factor responses to heavy resistance exercise protocols. Journal of Applied Physiology, 69(4), 1442–1450.
- Kubo, K., Ikebukuro, T., Yaeshima, K., Yata, H., & Tsunoda, N. (2019). Effects of squat training with different depths on lower limb muscle volumes. European Journal of Applied Physiology, 119(9), 1933–1942.
- O’Sullivan, K., McAuliffe, S., & DeBurca, N. (2012). The effects of eccentric training on lower limb flexibility: a systematic review. British Journal of Sports Medicine, 46(12), 838–845.
- Smilios, I., Pilianidis, T., Karamouzis, M., & Tokmakidis, S. P. (2003). Hormonal responses after various resistance exercise protocols. Medicine & Science in Sports & Exercise, 35(4), 644–654.
Key Takeaways
| Benefit | Mechanism | Supporting Evidence |
|---|---|---|
| Enhanced Hormonal Response | Increases GH, IGF-1, and regulates cortisol | Kraemer et al., 1990; Hansen et al., 2001; Smilios et al., 2003 |
| Improved Spinal and Bone Health | Axial loading stimulates BMD and disc health | Kohrt et al., 2004; Guadalupe-Grau et al., 2009; Belavy et al., 2017 |
| Increased RFD for Upper-Body Performance | Neural adaptation and cross-education effects | Haff et al., 2005; Carroll et al., 2006; Cormie et al., 2011 |
| Mobility Gains from Eccentric Loading | Deep ROM improves flexibility and joint health | O’Sullivan et al., 2012; Kubo et al., 2019; Hartmann et al., 2013 |
| Metabolic and Glucose Benefits | Greater GLUT-4 expression and EPOC | Holten et al., 2004; Borer et al., 2012 |