5 Smart Superset Combinations for Maximum Muscle Growth

| Jun 19, 2025 / 7 min read
Rowing supersets

Maximizing the efficiency in your gains and muscle growth in the gym is an ever-evolving process.  When you perform 5 smart superset combinations for maximal muscle growth, your efficiency can be through the roof. Supersets have been a tried-and-true technique used by body builders, athletes, and fitness regulars for building muscle, achieving gains, and maximizing results for decades.  

When combining the proper exercises for superset training, this technique can be a great way to achieve muscle growth and induce hypertrophy. The information ahead dives into ways to achieve maximal growth, combinations for muscle groups that hit results, and exercises that can be used for hypertrophy. 

Top 4 Ways to Achieve Muscle Growth 

To be efficient in building muscle, it is important to understand ways in which people develop muscle. Here are four methods that are common among many in the gym. 

  1. Progressive Overload.  This is a fundamental technique for building muscle. This technique states that there needs to be a continuous increase in stimulus to produce muscle gains. In this sense, the stimulus is more weight and the way to do that is to change what you lift.  Whether you are adding weight with each set or with each subsequent workout, more mass means more gains. 
  2. Pyramid Training. This type of training can be a great way to boost gains in a hurry. The type of pyramid you want to incorporate is up to you, but the progressive overload principal is met with every set with a pyramid. Here’s an example of pyramid sets you could incorporate for muscle growth. 
    • Heavy pyramids. 4 sets of: 10, 8, 6, 2-4 reps. Adding weight after each set is crucial and the last set should be a near maximal effort.  
    • Strength pyramids. Adding more weight is a constant with pyramids, but a pyramid set with more reps with slightly less weight can also be an option. An example would be 3 sets of: 15, 12, 10 with slightly less weight than the first pyramid. 
  3. Drop Sets. Adding drop sets to the mix brings a different type of training that can fatigue the muscles. Drop sets involve starting out with a set weight that ends up being a 6-8 repetition maximum. From here, you drop some weight and add reps.  A drop set would look something like this: 3 sets of: 6, 8 10 with heavy weight to start and more reps to finish. 
  4. Supersets. This type of training involves sets of exercises that are performed back-to-back with minimal rest periods. For example, a superset might include biceps curls with a triceps pulldown on consequent sets with no rest between.  There are various ways to perform supersets, but they typically deliver fast results.

Mixing and Matching Supersets Maximizes Your Effort

The combination of exercises you select for a superset can dictate the type of workout you get. While the main goal of supersets is to fatigue muscles, the pairing muscle group is important to take in consideration. 

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  • Opposite muscle groups. An example of this would be combining the biceps and triceps, back and chest. This option is ideal for hitting more muscle groups during your workout for overall full body strength. 
  • Same muscle group supersets.  This type of superset is best for split days when you are trying to fatigue certain muscle groups. You would work similar muscle groups, but perform different lifts to induce fast muscle fatigue. This type of superset should be performed gradually, since the amount of fatigue could cause soreness for days afterwards. 
  • Split body supersets.  For the regular lifter in the gym looking to hit full body gains, this might be the best type of superset. This combination involves upper and lower exercises with no rest between lifts. You can almost work it how you want and maximize your efforts in the gym, with time being the biggest factor. People who are strapped on time and want a full workout should look to this method. 

5 Amazing Benefits of Supersets 

The use of supersets in the gym isn’t just for bodybuilders; it’s a method that everyone can utilize. Especially for busy adults, athletes, and those looking for fast results, supersets can be a valuable tool to utilize from now on. Here’s are 5 amazing benefits of supersets anyone can expect.  

  1. Hypertrophy.  We all are looking to get stronger with our work in the gym, but if your goal is maximal muscle growth then this is for you. Studies show supersets can induce muscle hypertrophy in periodized training among athletes.
  2. Time efficient. If you are like many adults who want to work out and see results quickly then supersets may be for you. Since supersets have little to no rest between sets, the amount of time you’re sitting around waiting for her next lift is reduces and can significantly cut down on your workout time. 
  3. Fast gains. Especially if you incorporate opposing and same muscle groups, supersets can create muscle fatigue for fast gains. It cannot be overstated enough, but fast gains are essentially what everyone wants in the gym and supersets can help to get the body at that point. 
  4. Improved endurance. This doesn’t mean you’re working endurance as a long run, but the muscles that are worked in supersets must overcome fatigue to keep working, just like endurance training. While it might help you in your runs, the endurance gained here is having the strength to push through that last remaining rep. 
  5. Improved body composition. Of course, supersets can help you to grow muscle, but it can help to encourage more fat burning. Since there is a reduction in rest time, more muscle building, and it is very time efficient, the body utilizes more energy during and after exercise. With more energy used and more muscle created, body composition can dramatically be improved. 

5 Smart Superset Combinations for Maximal Muscle Growth 

Now that you have the basics, let’s look at 5 smart superset combinations for maximal muscle growth that you should try. 

  1. Bench Press and Seated Cable Row. This classic combination involves back and chest, which are more opposite muscle groups. If you have access to both the bench and cable machine, then this could be an incredible addition to your workout. 
  2. Biceps Curls and Triceps Pulldown.  A perfect superset combination, the biceps and triceps are opposite muscle groups that can help to show muscle growth in a hurry. Consider dumbbells, barbell curls, or cable curls to pair with the triceps cable pulldown for easy set up. 
  3. Back Squats and Romanian Deadlifts. This combination involves predominantly quads and hamstrings with a touch of glutes.  You should only need an Olympic bar to do this and your legs will feel the burn afterwards.
  4. Standing Barbell Press and Lat Pulldowns. The shoulders and Lats make a great superset combination given the overlap of muscle function. Consider using a barbell or dumbbells for the shoulder press for ease of use. 
  5. Bench Press and Dumbbell Fly. This same muscle group superset targets the pecs. For this combo, you can use a barbell for your bench press or dumbbells. However, a barbell may allow for more weight and better control than dumbbells. 

Things for Consideration with Supersets 

It should be stated that supersets are tough for everyone, but the results are above all. If you are taking up supersets to add to your regimen, make sure to warm up the body for at least 5-10 minutes. Warm-ups allow the muscles to loosen and get ready for the work ahead and may help to cut down on injuries. 

Another point to consider when performing your supersets is to avoid going too heavy too soon.  Often, athletes jump right in a superset routine and put on heavy weight for hypertrophy only to find that the body becomes super sore due to it not being familiar for the body. Ease into the lifts and the rewards will be there. 

Conclusion 

The addition of supersets in any workout and add to any muscle growth program and are generally easy to incorporate. Consider the information above as a complete guide on 5 smart superset combinations for maximal muscle growth and to help you to progress through your goals. 

Resources

https://pmc.ncbi.nlm.nih.gov/articles/PMC5556132

https://link.springer.com/article/10.1007/s40279-025-02176-8

https://pmc.ncbi.nlm.nih.gov/articles/PMC12011898

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