Discover what increasing testosterone does to muscle and strength and if it is necessary to have high levels of testosterone to be able to build muscle. Check out what an analysis of 18 scientific studies can provide.
When you talk about building muscle, it is common to talk about testosterone. After all, testosterone has long been hailed as a pivotal factor influencing the extent of muscle hypertrophy. However, the narrative surrounding testosterone’s role in muscle growth is far more intricate than often perceived. Common beliefs, such as the assumption that higher testosterone levels universally lead to superior muscle gains, need careful examination to uncover the nuanced reality.
As we embark on this exploration, it becomes apparent that distinguishing between between-people data and within-person effects is crucial for a comprehensive understanding. The broader context reveals that individuals with lower testosterone levels can still achieve noteworthy muscle gains, challenging the simplistic notion of a linear relationship between testosterone and hypertrophy.

The information used for this article was based on a video shared by House of Hypertrophy. See it all below.
Our aim here is to unravel the layers of complexity surrounding the testosterone-muscle hypertrophy connection. By delving into scientific studies, we seek to dissect the intricate dynamics that govern how testosterone impacts muscle growth, clarifying misconceptions and providing a foundation for a more nuanced perspective on this physiological interplay.
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What Increasing Testosterone Does to Muscle and Strength
A common misconception arises from interpreting between-people data, which compares muscle growth in individuals with varying testosterone levels. The truth is that people with higher testosterone levels do not necessarily experience more muscle growth than those with lower levels. It’s essential to differentiate between between-people data and within-person effects when evaluating the relationship between testosterone and muscle hypertrophy.
Between-People Data:
Studies examining between-people relationships reveal that individuals with lower testosterone levels can still build more muscle than those with higher levels. Factors beyond testosterone, such as regulators of hypertrophy, play a crucial role in determining muscle growth. For example, a person with lower testosterone levels may exhibit superior muscle gains if other regulators are optimized.

Within-Person Effects:
The critical distinction lies in understanding the within-person effects of testosterone. When examining whether increasing the testosterone levels of a single person directly enhances their muscle and strength gains from training, the answer is yes. However, this increase primarily affects the baseline muscle and strength rather than synergistically enhancing gains from training.
Scientific Studies:
Several studies support the notion that increasing testosterone levels predominantly leads to baseline muscle and strength gains, not direct improvements from training. One study involved supraphysiological testosterone levels, showing additive rather than synergistic effects on muscle and strength gains. Another study examined less extreme increases in testosterone, demonstrating small but notable baseline gains.
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Impact of Natural Means:
While non-natural methods were used in the studies, it’s essential to consider the potential impact of naturally increasing testosterone levels. Managing body fat levels, correcting nutritional deficiencies, optimizing sleep, and reducing chronic stress can contribute to natural testosterone increases. However, the effects of natural increases on muscle and strength gains are comparatively small.

Potential Synergistic Effects of Supraphysiological Levels:
Exploring the potential synergistic effects of supraphysiological testosterone levels introduces intriguing possibilities. These elevated levels might enhance an individual’s work capacity, expedite recovery between training sessions, and contribute to an increased number of myonuclei in muscle fibres. While these theories offer promising avenues, further research is essential to validate and comprehensively understand the interplay of these factors.
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Conclusion:
In conclusion, comprehending the multifaceted relationship between testosterone and muscle hypertrophy is pivotal for a nuanced understanding of fitness. The dichotomy between between-people data and within-person effects highlights the context-specific nature of testosterone’s influence. Furthermore, the impact of natural means on testosterone levels underscores the importance of a holistic approach to fitness. The exploration of potential synergistic effects at supraphysiological levels adds an intriguing layer to the conversation, inviting further research and a deeper understanding of this intricate physiological interplay.
For a deeper explanation regarding what increasing testosterone does to muscle and strength, you can simply watch the video below.
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The 18 scientific studies mentioned during the video and used for the article were:
- The Effects of Supraphysiologic Doses of Testosterone on Muscle Size and Strength in Normal Men
- Effects of testosterone and resistance training in men with chronic obstructive pulmonary disease
- Pharmacokinetics, efficacy, and safety of a permeation-enhanced testosterone transdermal system in comparison with bi-weekly injections of testosterone enanthate for the treatment of hypogonadal men
- Testosterone and exercise: effects on fitness, body composition, and strength in middle-to-older aged men with low-normal serum testosterone levels
- Testosterone dose-response relationships in healthy young men
- Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle
- Effect of testosterone supplementation with and without a dual 5α-reductase inhibitor on fat-free mass in men with suppressed testosterone production: a randomized controlled trial
- Testosterone administration to older men improves muscle function: molecular and physiological mechanisms
- Testosterone replacement increases fat-free mass and muscle size in hypogonadal men
- Effects of Graded Whey Supplementation During Extreme-Volume Resistance Training
- Effects of High-Volume Versus High-Load Resistance Training on Skeletal Muscle Growth and Molecular Adaptations
- Training Volume, Not Frequency, Indicative of Maximal Strength Adaptations to Resistance Training
- The male contraceptive regimen of testosterone and levonorgestrel significantly increases lean mass in healthy young men in 4 weeks, but attenuates a decrease in fat mass induced by testosterone alone
- Gonadal steroids and body composition, strength, and sexual function in men
- Testosterone deficiency in young men: marked alterations in whole body protein kinetics, strength, and adiposity
- Suppression of endogenous testosterone production attenuates the response to strength training: a randomized, placebo-controlled, and blinded intervention study
- Testosterone-induced increase in muscle size in healthy young men is associated with muscle fiber hypertrophy
- Muscle Fiber Hypertrophy and Myonuclei Addition: A Systematic Review and Meta-analysis
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Learn More
Testosterone, a key male sex hormone, plays a vital role in the process of building and maintaining muscle mass. One of the primary ways testosterone contributes to muscle growth is by stimulating protein synthesis. Protein synthesis is the biological process where cells build proteins, and in the context of muscle, this translates to the creation of new muscle tissue.
Moreover, testosterone enhances the production of growth hormone, another crucial player in muscle development. Growth hormone stimulates the growth and regeneration of cells, including muscle cells. Together, testosterone and growth hormone create an environment conducive to muscle hypertrophy, promoting the increase in muscle fibre size and overall muscle mass.
In addition to facilitating protein synthesis, testosterone also has a role in reducing muscle protein breakdown. This dual action – promoting the building of new muscle proteins while limiting the breakdown of existing ones – is pivotal in achieving a positive muscle protein balance, a key factor for muscle growth.
Beyond the cellular level, testosterone enhances the formation of myonuclei, the central components in muscle fibres responsible for protein synthesis and overall muscle function. Higher testosterone levels contribute to an increased number of myonuclei, creating a more favourable environment for sustained muscle growth.
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Testosterone and Weight Loss:
While testosterone is often associated with muscle building, its influence extends to the realm of weight management, including weight loss. The intricate relationship between testosterone and body composition is multifaceted and goes beyond merely building muscle.
Testosterone impacts metabolism, influencing the body’s ability to burn calories and utilise energy efficiently. Higher testosterone levels are associated with increased metabolic rate, promoting the burning of calories even at rest. This heightened metabolic activity can contribute to weight loss, especially in the form of reducing body fat.
Furthermore, testosterone plays a role in fat distribution, particularly in males. It encourages the preferential storage of fat in the abdominal area rather than in peripheral areas. This centralised fat distribution is associated with a lower risk of metabolic disorders and is often linked to better weight management.
However, it’s important to note that the relationship between testosterone and weight loss is complex and can be influenced by various factors. For instance, low testosterone levels may be associated with decreased energy levels and motivation, potentially impacting exercise and physical activity. This, in turn, can have implications for weight management.
In summary, testosterone serves as a multifaceted hormone that not only plays a pivotal role in muscle building but also influences metabolic processes crucial for weight management. Achieving a balance in testosterone levels through lifestyle factors such as regular exercise, a balanced diet, and sufficient sleep can contribute to both muscle development and weight regulation.
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image sources
- Chest pumped: Tima Miroshnichenko on Pexels
- Strong legs: Alora Griffiths
- Rope pushdown (2): Daniel Apodaca on Unsplash
- Age Group Online Qualifier 2021: Courtesy of CrossFit Inc.
- Resistance band (1): Ricky Nugraha on Pexels